The sequel begins in a Sicilian monastery. Hitman tries to distance himself from his violent past, but he fails when discovered by a Russian crime lord and tricked into returning to his trade. But soon he discovers that he has been manipulated and is now a target himself - of a highly trained ex-Spetsnaz assassin.
So you as Hitman have to accomplish missions by eliminating primary targets in multiple play styles, carrying weapons and equipment from mission to mission.